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Physicians Perspective : Hodgkin DiseaseWhat Is the Role for Radiation Therapy?
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by tcc, 2011-04-19 21:04, 人氣(6074)
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1.
Hodgkin DiseaseWhat Is the Role for Radiation Therapy?
2.
Overview
3.
Radiation and Chemotherapy for Hodgkin’s Disease Are Nothing New
4.
Survival is Improving
5.
The Bad News
6.
The Good and Bad News (Obstacles to Improvement)
7.
Cotswolds Staging System
8.
Cotswolds Staging System (2)
9.
HD Prognostic Groups
10.
Treatment Considerations
11.
Slide 11
12.
Recommended TreatmentFavorable CS I-IIA
13.
The Radiotherapeutic Option for Selected Patients
14.
Recommended TreatmentUn-favorable Non-bulky CS I-IIA
15.
Intermediate Stage HDABVD + RT (STNI vs IFRT)
16.
Intermediate Stage HDABVD + RT (STNI vs IFRT)
17.
Recommended TreatmentUn-favorable Bulky CS I-IIA
18.
Recommended TreatmentCS III-IV
19.
Advanced Disease
20.
Slide 19
21.
Slide 20
22.
Leukemogenesis
23.
Secondary AML or MDS
24.
Second Malignancies in HD1319 Cases Followed
25.
Breast Cancer and Mantle RT
26.
Is chemotherapy alone adequate for favorable disease?
27.
CT/RT vs. CT for HD
28.
NCIC/ECOGTrial Design
29.
NCIC/ECOG
30.
NCIC/ECOG
31.
MSKCC ABVD±Mantle RT
32.
ABVD Alone for CS I-II
33.
Slide 32
34.
What about RT in more advanced disease?
35.
So, what does this mean?
36.
What about RT in more advanced disease?
37.
Meta-analysis
38.
Meta-Analysis Concerns
39.
Consolidation RT Following CR to ABVD
40.
Cautions in Interpretation
41.
A Randomized Phase III Trial of ABVD vs Stanford V +/- Radiation Therapy in Locally Extensive and Advanced Stage Hodgkin’s Lymphoma: An Intergroup Study Coordinated by the EasternCooperative Oncology Group (E2496)
42.
Study Schema
43.
ABVD and Stanford V Chemotherapy Regimens
44.
FFS ABVD vs. Stanford V
45.
Author Conclusions
46.
FDG/PET2 vs IPI
47.
Early Interim 18F-FDG PET in Hodgkin’s Lymphoma: Evaluation on 304 Patients
48.
Results (from Abstract)
49.
Study Schema
50.
Results (from Abstract)
51.
Can We Reduce Field Size Further
52.
Radiation Carcinogenesis
53.
Author Conclusion
54.
Radiation Carcinogenesis
55.
Slide 57
56.
Slide 57
57.
Slide 58
58.
Slide 59
59.
What about IMRT?
60.
What about IMRT?
61.
IMRT for Mediastinal HD MSKCC
62.
IMRT for Mediastinal HDIGR
63.
Total Body Dose
64.
Slide 65
65.
Slide 67
66.
Slide 68
67.
Conclusions
68.
Slide 70
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